{"id":5342,"date":"2021-05-10T06:37:46","date_gmt":"2021-05-10T06:37:46","guid":{"rendered":"http:\/\/3.35.173.53\/?p=5342"},"modified":"2021-07-15T12:00:40","modified_gmt":"2021-07-15T03:30:40","slug":"significant-association-of-drd2enhancer-variant-rs12364283-with-heroin-addiction-in-a-pakistani-population","status":"publish","type":"post","link":"https:\/\/happyfinder.co.kr\/?p=5342","title":{"rendered":"Significant association of DRD2enhancer variant rs12364283 with heroin addiction in a Pakistani population"},"content":{"rendered":"

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SHORT COMMUNICATION<\/span><\/span><\/div>\n

Significant association of<\/span> <\/span>DRD2<\/span> <\/span><\/i>enhancer variant rs12364283 with heroin addiction in a Pakistani population<\/span><\/h1>\n
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Abstract<\/span><\/h3>\n

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The dopamine D2 receptor encoded by<\/span> <\/span>DRD2<\/span> <\/span><\/i>has been implicated in multiple psychiatric disorders, mediated at least in part by two intronic variants affecting mRNA splicing, rs1076560 and rs2283265, and a less frequent enhancer variant, rs12364283, which increases<\/span> <\/span>DRD2<\/span> <\/span><\/i>mRNA expression. This study tests whether these functionally validated variants confer susceptibility toward heroin addiction in a Pakistani population. A total of 540 heroin addicts and 467 healthy controls were genotyped, basic allele and genotype tests were performed. Neither rs1076560 nor rs2283265 significantly associated with heroin addiction. The enhancer rs12364283 occurs more frequently in heroin\u2010dependent cases than controls (MAF 13% vs. 7%, respectively), revealing significant association with heroin addiction (<\/span>p<\/span> <\/span><\/i> = 3.0E\u201006, OR 2.1). This study identifies rs12364283 of<\/span> <\/span>DRD2<\/span> <\/span><\/i>as a potential risk factor for heroin addiction in the Pakistani study population. This enhancer variant had been shown to increase<\/span> <\/span>DRD2<\/span> <\/span><\/i>mRNA expression, a possible factor in increased vulnerability to heroin addiction. Further studies are needed to validate this association of rs12364283.<\/span><\/p>\n<\/div>\n<\/div>\n

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Jabeen, Shagufta, Julia K. Pinsonneault, Wolfgang Sadee, Sung\u2010Ha Lee, Muhammad Mobeen Zafar, Muhammad Saqlain Raja, and Ghazala Kaukab Raja. “Significant association of DRD2 enhancer variant rs12364283 with heroin addiction in a Pakistani population.” <\/span>Annals of human genetics<\/span><\/i> 83, no. 5 (2019): 367-372.<\/span> <\/p>\n

https:\/\/doi.org\/10.1111\/ahg.12322<\/span><\/a> <\/span><\/p>\n

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  SHORT COMMUNICATION Significant association of DRD2 enhancer variant rs12364283 with heroin addiction in a Pakistani population Abstract The dopamine D2 receptor encoded by DRD2 has been implicated in multiple psychiatric disorders, mediated at least in part by two intronic variants affecting mRNA splicing, rs1076560 and rs2283265, and a less frequent enhancer variant, rs12364283, which increases DRD2 mRNA expression. This study […]<\/p>\n","protected":false},"author":2,"featured_media":11198,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jnews-multi-image_gallery":[],"jnews_single_post":{"subtitle":"","format":"standard","video":"","gallery":"","source_name":"","source_url":"","via_name":"","via_url":"","override":[{"single_blog_custom":"","sidebar":"","second_sidebar":"","share_position":"","share_float_style":"","post_date_format":"","post_date_format_custom":"","post_reading_time_wpm":"","zoom_button_out_step":"1","zoom_button_in_step":"1","number_popup_post":"1"}],"image_override":[{"single_post_thumbnail_size":"","single_post_gallery_size":""}],"trending_post_position":"","trending_post_label":"","sponsored_post_label":"","sponsored_post_name":"","sponsored_post_url":"","sponsored_post_logo":"","sponsored_post_desc":""},"jnews_primary_category":{"id":""},"jnews_social_meta":{"fb_title":"","fb_description":"","fb_image":"","twitter_title":"","twitter_description":"","twitter_image":""},"jnews_override_counter":{"view_counter_number":"0","share_counter_number":"0","like_counter_number":"0","dislike_counter_number":"0"},"footnotes":""},"categories":[15,29],"tags":[1489,1215],"_links":{"self":[{"href":"https:\/\/happyfinder.co.kr\/index.php?rest_route=\/wp\/v2\/posts\/5342"}],"collection":[{"href":"https:\/\/happyfinder.co.kr\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/happyfinder.co.kr\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/happyfinder.co.kr\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/happyfinder.co.kr\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=5342"}],"version-history":[{"count":2,"href":"https:\/\/happyfinder.co.kr\/index.php?rest_route=\/wp\/v2\/posts\/5342\/revisions"}],"predecessor-version":[{"id":11199,"href":"https:\/\/happyfinder.co.kr\/index.php?rest_route=\/wp\/v2\/posts\/5342\/revisions\/11199"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/happyfinder.co.kr\/index.php?rest_route=\/wp\/v2\/media\/11198"}],"wp:attachment":[{"href":"https:\/\/happyfinder.co.kr\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=5342"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/happyfinder.co.kr\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=5342"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/happyfinder.co.kr\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=5342"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}