Two independent types of experiences of depression have been identified among normals—dependency and self-criticism. Using the Depressive Experiences Questionnaire, this study investigates their utility in differentiating depression in patients. 197 patients (mean age 34 yrs) and 262 normal controls (mean age 26.7 yrs) also completed the MMPI, Beck Depression Inventory, and Self Rating Depression Scale. There were consistent differences among patients as a function of whether their experiences of depression focused primarily on issues of dependency and/or self-criticism or an absence of these issues. The subjective experiences around which an individual’s depression focuses seem to provide a valid basis for differentiating among types of depression. Judges using case records were able to differentiate patients who were high on dependency or self-criticism, on both, or on neither of these dimensions. The distinction between these 2 different foci of depression may provide valuable differentiations for clinical research, and have important implications for the therapeutic process with different types of depressed patients.